Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14041306 | 0.88 | RIPK1 (0.48) | RIPK1POLBPIK3CAMTORPIK3CG | |
| SCHEMBL3078427 | 0.88 | LRRK2 (0.48) | RIPK1PIK3CAMTORPIK3CGATR | |
| SCHEMBL14041305 | 0.88 | RIPK1 (0.48) | RIPK1POLBPIK3CAMTORPIK3CG | |
| SCHEMBL4936226 | 0.84 | RIPK1 (0.55) | RIPK1POLBPIK3CAMTORPIK3CG | |
| SCHEMBL14041303 | 0.83 | JAK2 (0.47) | RIPK1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL3087718 | 0.80 | PARP1 (0.43) | KMT2APARP1AXLHPGD | |
| SCHEMBL3083372 | 0.79 | RHEB (0.54) | KMT2AHPGD | |
| SCHEMBL4020886 | 0.79 | POLB (0.54) | RIPK1POLBPIK3CAMTORPIK3CG | |
| SCHEMBL16243354 | 0.79 | ALK (0.64) | — | |
| Hydrochloric Acid SCHEMBL4936823 | 0.78 | POLB (0.53) | RIPK1POLBPIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121064-A1 | NEW IMIDAZO[4,5-B]PYRIDINE-6-HALO-7-ARYL/HETEROARYL COMPOUNDS 705 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008121064-A1 | NEW IMIDAZO[4,5-B]PYRIDINE-6-HALO-7-ARYL/HETEROARYL COMPOUNDS 705 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |