Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083372 | 0.86 | RHEB (0.54) | KDM4EALDH1A1HPGDKMT2AGAA | |
| SCHEMBL3091719 | 0.85 | TBK1 (0.53) | PARP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3090291 | 0.85 | TGFBR1 (0.44) | PARP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3078427 | 0.80 | LRRK2 (0.48) | HPGD | |
| SCHEMBL4909647 | 0.80 | KDM4E (0.47) | PARP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL4748880 | 0.80 | RIPK1 (0.48) | PARP1HPGDKMT2AAXL | |
| SCHEMBL4934480 | 0.79 | KDM4E (0.48) | PARP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3084527 | 0.73 | RHEB (0.56) | KDM4EALDH1A1HPGDKMT2AMMP2 | |
| SCHEMBL4940706 | 0.73 | KDM4E (0.48) | PARP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL15172625 | 0.73 | ALK (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | claimed |
| CN-101679421-A | Novel imidazo [4, 5-b ] pyridine-7-carboxamides 704 | ASTRAZENECA AB | 2010-03-24 | — | — | CN | claimed |
| EP-2142542-A1 | NEW IMIDAZO [4,5-B] PYRIDINE-7-CARBOXAMIDES 704 | AstraZeneca AB (SE) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121063-A1 | NEW IMIDAZO[ 4,5-B]PYRIDINE-7-CARBOXAMIDES 704 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | claimed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| CN-101679421-A | Novel imidazo [4, 5-b ] pyridine-7-carboxamides 704 | ASTRAZENECA AB | 2010-03-24 | — | — | CN | disclosed |
| EP-2142542-A1 | NEW IMIDAZO [4,5-B] PYRIDINE-7-CARBOXAMIDES 704 | AstraZeneca AB (SE) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121063-A1 | NEW IMIDAZO[ 4,5-B]PYRIDINE-7-CARBOXAMIDES 704 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008121063-A1 | NEW IMIDAZO[ 4,5-B]PYRIDINE-7-CARBOXAMIDES 704 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008121064-A1 | NEW IMIDAZO[4,5-B]PYRIDINE-6-HALO-7-ARYL/HETEROARYL COMPOUNDS 705 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | HDAC4, HDAC7, BRD4 | PARP1 1771/4885KDM4E 172/4885ALDH1A1 988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.