Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751222 | 0.85 | SMN1; SMN2 (0.58) | ALDH1A1POLBKMT2AATMKDM4E | |
| SCHEMBL990427 | 0.84 | KCNH2 (0.50) | ALDH1A1POLBGRM2MCHR1 | |
| SCHEMBL3149433 | 0.84 | ALDH1A1 (0.50) | ALDH1A1POLBGRM2KMT2AATM | |
| SCHEMBL17468364 | 0.84 | CXCR4 (0.55) | ALDH1A1POLBKMT2AATMKDM4E | |
| SCHEMBL1427302 | 0.84 | ALDH1A1 (0.47) | ALDH1A1POLBKMT2AATMKDM4E | |
| SCHEMBL220097 | 0.83 | SIGMAR1 (0.62) | ALDH1A1KMT2AATMSMN1; SMN2MEN1 | |
| SCHEMBL21133116 | 0.83 | ALDH1A1 (0.53) | ALDH1A1POLBGRM2MCHR1KMT2A | |
| SCHEMBL14045873 | 0.83 | CXCR4 (0.55) | ALDH1A1POLBGRM2MCHR1KMT2A | |
| SCHEMBL6707988 | 0.81 | KMT2A (0.43) | ALDH1A1POLBGRM2KMT2AATM | |
| SCHEMBL27713409 | 0.80 | ALDH1A1 (0.53) | ALDH1A1POLBGRM2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | claimed |
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |