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SCHEMBL4749156

SCHEMBL4749156

Cc1c(F)cccc1C1C(C(=O)c2cccc(O)c2)CN(CCC(N)C(C)(C)C)CC1C(=O)[C@@H]1CN(CCC(N)C(C)(C)C)C[C@H](C(=O)c2cccc(O)c2)[C@@H]1c1cccc(F)c1C

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ KDM2B Q8NHM5 2/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4749179 1.00 KDM2B (0.31) KDM2BMEN1KMT2A
SCHEMBL4751971 0.88 KDM2B (0.30) KDM2B
SCHEMBL4751978 0.88 KDM2B (0.30) KDM2B
SCHEMBL4751355 0.87 KDM2B (0.33) KDM2BMEN1KMT2A
SCHEMBL4752015 0.87 KIF11 (0.34) KDM2BMEN1KMT2A
SCHEMBL4751349 0.87 KDM2B (0.33) KDM2BMEN1KMT2A
SCHEMBL4752024 0.87 KIF11 (0.34) KDM2BMEN1KMT2A
SCHEMBL4751597 0.86 DRD3 (0.33) KDM2BMEN1KMT2A
SCHEMBL13720775 0.85 MEN1 (0.35) KDM2BMEN1KMT2A
SCHEMBL4024540 0.85 MEN1 (0.35) KDM2BMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008140810-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-11-20 — — WO claimed
WO-2008140810-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-11-20 — — WO disclosed