SCHEMBL4751971

Cc1c(F)cccc1C1C(C(=O)c2cccc(O)c2)CN(CCC(N(C)C)C(C)(C)C)CC1C(=O)[C@@H]1CN(CCC(N(C)C)C(C)(C)C)C[C@H](C(=O)c2cccc(O)c2)[C@@H]1c1cccc(F)c1C

nearest known ligand 0.30

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	KDM2B	Q8NHM5	2/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4751978	1.00	KDM2B (0.30)	KDM2B
SCHEMBL4749179	0.88	KDM2B (0.31)	KDM2B
SCHEMBL4749156	0.88	KDM2B (0.31)	KDM2B
SCHEMBL4749085	0.87	HTR1A (0.31)	KDM2B
SCHEMBL4749073	0.87	HTR1A (0.31)	KDM2B
SCHEMBL4779051	0.86	KDM4E (0.36)	KDM2B
SCHEMBL4749303	0.85	KDM2B (0.31)	KDM2B
SCHEMBL4749092	0.85	KDM2B (0.31)	KDM2B
SCHEMBL4749084	0.85	KDM2B (0.31)	KDM2B
SCHEMBL4749288	0.85	KDM2B (0.31)	KDM2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008140810-A1	CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS	CYTOKINETICS, INCORPORATED (US)	2008-11-20	—	—	WO	claimed
WO-2008140810-A1	CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS	CYTOKINETICS, INCORPORATED (US)	2008-11-20	—	—	WO	disclosed