Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.45 |
| ▸ | RBP4 | P02753 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752746 | 0.93 | MC4R (0.44) | MC4RRBP4KMT2AGSK3BLMNA | |
| SCHEMBL4752007 | 0.89 | MC4R (0.45) | MC4RRBP4KMT2ALMNA | |
| SCHEMBL4751974 | 0.86 | MC4R (0.37) | MC4RRBP4KMT2AGSK3BLYN | |
| SCHEMBL4749130 | 0.85 | MC4R (0.44) | MC4RRBP4KMT2A | |
| SCHEMBL4751347 | 0.85 | MC4R (0.44) | MC4RRBP4KMT2A | |
| SCHEMBL4751369 | 0.83 | MC4R (0.42) | MC4RRBP4KMT2AGSK3BLYN | |
| SCHEMBL4776626 | 0.83 | MC4R (0.44) | MC4RRBP4KMT2A | |
| SCHEMBL4776650 | 0.83 | MC4R (0.44) | MC4RRBP4KMT2ALMNA | |
| SCHEMBL4751319 | 0.83 | MC4R (0.41) | MC4RRBP4KMT2AHRH3 | |
| SCHEMBL4794920 | 0.82 | MC4R (0.44) | MC4RRBP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |