Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787145 | 0.88 | KMT2A (0.64) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL5294918 | 0.86 | MAPK8 (0.68) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL28722481 | 0.84 | MAPK8 (0.66) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL16760967 | 0.84 | MAPK8 (0.66) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL7933290 | 0.84 | MAPK8 (0.66) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL5106577 | 0.83 | KMT2A (0.66) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL4864158 | 0.81 | MAPK8 (0.61) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL4959294 | 0.81 | ALDH1A1 (0.63) | SMN1; SMN2HPGDKMT2ALMNACASP3 | |
| SCHEMBL1367369 | 0.80 | NPC1 (0.71) | SMN1; SMN2HPGDKMT2ALMNAATM | |
| SCHEMBL1039299 | 0.80 | MAPK8 (1.00) | SMN1; SMN2HPGDKMT2ALMNACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140214-A1 | USE OF AMINOTHIOPHENE DERIVATIVE FOR PREVENTING OR TREATING ISCHEMIC DISEASES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-11-20 | — | — | WO | disclosed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |