Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17817419 | 0.94 | ALDH1A1 (0.60) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL5106577 | 0.91 | KMT2A (0.66) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL4958864 | 0.85 | ABCC1 (0.60) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL4787145 | 0.84 | KMT2A (0.64) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL24104683 | 0.84 | MAPK8 (0.62) | ALDH1A1KMT2ATDP1MEN1MAPT | |
| SCHEMBL5294918 | 0.82 | MAPK8 (0.68) | ALDH1A1KMT2AMEN1MAPTCASP3 | |
| SCHEMBL7933290 | 0.81 | MAPK8 (0.66) | ALDH1A1KMT2AMEN1MAPTCASP3 | |
| SCHEMBL28722481 | 0.81 | MAPK8 (0.66) | ALDH1A1KMT2AMEN1MAPTCASP3 | |
| SCHEMBL4749588 | 0.81 | SMN1; SMN2 (0.67) | ALDH1A1KMT2AMEN1MAPTCASP3 | |
| SCHEMBL16760967 | 0.81 | MAPK8 (0.66) | ALDH1A1KMT2AMEN1MAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |