Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749582 | 0.83 | KDM4E (0.72) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4749602 | 0.83 | KDM4E (0.72) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL14042098 | 0.82 | LMNA (0.61) | KDM4EMAPTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL4749789 | 0.79 | KDM4E (0.71) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4750237 | 0.78 | KDM4E (0.69) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2753997 | 0.78 | KMT2A (0.73) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4746906 | 0.78 | KDM4E (0.68) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL24107726 | 0.77 | ADORA3 (0.71) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL24107602 | 0.77 | ADORA3 (0.71) | ADORA3KDM4EMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4787610 | 0.77 | KDM4E (0.57) | KDM4EMAPTSMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |