Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 2/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749628 | 1.00 | GRK6 (0.42) | GRK6MCOLN3NPC1MAPTMAPK1 | |
| SCHEMBL14041860 | 0.87 | LMNA (0.46) | GRK6NPC1MAPTMAPK1ALDH1A1 | |
| SCHEMBL30960353 | 0.83 | APP (0.44) | NPC1MAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL4746315 | 0.82 | TP53 (0.37) | NPC1MEN1KMT2ASMN1; SMN2CYP2C9 | |
| SCHEMBL11909744 | 0.78 | KAT2B (0.45) | GRK6MCOLN3MAPTMAPK1ALDH1A1 | |
| SCHEMBL11909741 | 0.78 | KAT2B (0.45) | GRK6MCOLN3MAPTMAPK1ALDH1A1 | |
| SCHEMBL11272299 | 0.76 | MAPT (0.47) | NPC1MAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL11272273 | 0.76 | MAPT (0.47) | NPC1MAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL11836392 | 0.74 | PKM (0.45) | NPC1MAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL4749021 | 0.74 | MAPT (0.44) | GRK6MCOLN3NPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119718-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |