Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22407654 | 0.99 | LMNA (0.97) | LMNACYP1A2CYP2D6CYP2C19RECQL | |
| SCHEMBL15092656 | 0.99 | LMNA (0.97) | LMNACYP1A2CYP2D6CYP2C19RECQL | |
| SCHEMBL18040093 | 0.87 | LMNA (0.78) | LMNAALDH1A1HTTKDM4EMEN1 | |
| SCHEMBL6323061 | 0.87 | LMNA (0.78) | LMNAALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4746764 | 0.86 | LMNA (0.75) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4749971 | 0.85 | LMNA (0.73) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3260049 | 0.83 | CYP2D6 (0.95) | LMNACYP1A2CYP2D6CYP2C19RECQL | |
| SCHEMBL4749180 | 0.83 | LMNA (0.71) | LMNACYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL3223889 | 0.83 | LMNA (0.70) | LMNACYP1A2CYP2D6CYP2C19RECQL | |
| SCHEMBL3207575 | 0.82 | CYP2D6 (0.97) | LMNACYP1A2CYP2D6CYP2C19RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008122667-A2 | UREYLENE DERIVATIVES | SCHOOL OF PHARMACY (GB) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008122667-A2 | UREYLENE DERIVATIVES | SCHOOL OF PHARMACY (GB) | 2008-10-16 | — | — | WO | disclosed |