Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4577386 | 0.84 | LMNA (0.66) | LMNAHTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4750163 | 0.83 | LMNA (1.00) | LMNAHTTALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4578026 | 0.82 | CCR3 (0.69) | LMNAHTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3224693 | 0.82 | NPC1 (0.63) | LMNAHTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22407654 | 0.82 | LMNA (0.97) | LMNAHTTALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL15092656 | 0.82 | LMNA (0.97) | LMNAHTTALDH1A1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL3211216 | 0.81 | NPC1 (0.62) | LMNAHTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL18040093 | 0.80 | LMNA (0.78) | LMNAHTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6323061 | 0.80 | LMNA (0.78) | LMNAHTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3207988 | 0.79 | ALDH1A1 (0.65) | LMNAALDH1A1CYP2C19CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8519139-B2 | Indazolamides with analgesic activity | Aziende Chimeche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2013-08-27 | — | — | US | disclosed |
| EP-1594859-B1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | ACRAF (IT) | 2010-06-23 | — | — | EP | disclosed |
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2010-02-25 | — | — | US | disclosed |
| US-7632849-B2 | N3-((1-(2-Oxo-2-(phenylamino)ethyl)-4-piperidyl)methyl)- 1-(1-methylethyl)-1H-indazole-3-carboxamide; antiarthritic agents; rheumatic diseases; osteoarthritis; fibromyaleia;anticarcinogenic agents, pain; neuropathic pain; immunoincompetance; trauma; antiischemic agents; multiple sclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-15 | — | — | US | disclosed |
| US-20060052417-A1 | Indazolamides with analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2006-03-09 | — | — | US | disclosed |
| EP-1594859-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074275-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | TRPV1, CA2, TRPV2 | LMNA 2839/4885HTT 2362/4885ALDH1A1 571/4885 |
| US-20060052417-A1 | Indazolamides with analgesic activity | P2RX7, P2RX3, P2RX1 | LMNA 1830/4885HTT 1696/4885ALDH1A1 870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.