Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.36 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753615 | 0.78 | HDAC8 (0.41) | HTTSMN1; SMN2PLA2G7MGLLABHD6 | |
| SCHEMBL10173626 | 0.73 | ALDH1A1 (0.39) | HTTSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL4751782 | 0.72 | POLB (0.59) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL8999777 | 0.69 | GABRP (0.41) | HTTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4751942 | 0.68 | HDAC8 (0.38) | SMN1; SMN2MGLLMEN1KMT2APOLB | |
| SCHEMBL27988389 | 0.68 | KDM4E (0.51) | KDM4E | |
| SCHEMBL4284114 | 0.67 | MCHR1 (0.35) | KDM5ATSHR | |
| SCHEMBL1774699 | 0.66 | KDM4E (0.44) | HTTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4290291 | 0.65 | MCHR1 (0.34) | TSHR | |
| SCHEMBL28251554 | 0.65 | BRD4 (0.43) | MEN1KMT2APOLBNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |