Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 10/20 | 0.32 |
| ▸ | LCK | P06239 | 9/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750933 | 0.92 | KDM4E (0.41) | MERTKTNK2LCKKDREGFR | |
| SCHEMBL4748341 | 0.86 | ITGB1 (0.31) | MERTK | |
| SCHEMBL1786399 | 0.78 | ALOX5AP (0.41) | MERTKTNK2LCK | |
| Formic Acid SCHEMBL1787399 | 0.74 | ALOX5AP (0.38) | MERTKTNK2EGFR | |
| SCHEMBL1784897 | 0.72 | AURKA (0.39) | TNK2KDREGFRKDM4EALDH1A1 | |
| SCHEMBL14467227 | 0.72 | AURKA (0.36) | MERTKTNK2LCKEGFRKDM4E | |
| SCHEMBL3124995 | 0.72 | MERTK (0.34) | MERTKTNK2LCKKDRKDM4E | |
| SCHEMBL1787745 | 0.72 | AURKA (0.36) | MERTKTNK2LCKEGFRKDM4E | |
| SCHEMBL3125001 | 0.72 | AURKA (0.36) | MERTKTNK2LCKEGFRKDM4E | |
| SCHEMBL4750648 | 0.72 | LCK (0.41) | TNK2LCKKDREGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131859-A2 | USE OF CYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |