Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.52 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28592105 | 0.84 | KDM4E (0.52) | LMNAKDM4ECYP1A2CYP2D6MEN1 | |
| Phenylpropanol SCHEMBL27734478 | 0.80 | LMNA (0.86) | LMNAKDM4EMEN1KMT2ARIPK1 | |
| Citric Acid SCHEMBL8508556 | 0.80 | LMNA (0.62) | LMNAKDM4ECYP1A2CYP2D6MEN1 | |
| Citric Acid SCHEMBL19895397 | 0.79 | MAPT (0.52) | LMNAKDM4ECYP1A2CYP2D6MEN1 | |
| Phenylpropanol SCHEMBL8190441 | 0.79 | LMNA (0.83) | LMNAKDM4EMEN1KMT2ARIPK1 | |
| Phenylpropanol SCHEMBL539164 | 0.78 | LMNA (1.00) | LMNAKDM4ECYP1A2CYP2D6ALDH1A1 | |
| Phenylpropanol SCHEMBL56673 | 0.78 | LMNA (1.00) | LMNAKDM4ECYP1A2CYP2D6ALDH1A1 | |
| Phenylpropanol SCHEMBL27691663 | 0.78 | LMNA (1.00) | LMNAKDM4ECYP1A2CYP2D6ALDH1A1 | |
| Phenylpropanol SCHEMBL698860 | 0.78 | LMNA (1.00) | LMNAKDM4ECYP1A2CYP2D6ALDH1A1 | |
| Phenylpropanol SCHEMBL27878996 | 0.78 | LMNA (1.00) | LMNAKDM4ECYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008129494-A1 | ANTIMICROBIAL PRESERVATIVE FREE WIPE | THE PROCTER & GAMBLE COMPANY (US) | 2008-10-30 | — | — | WO | disclosed |