SCHEMBL4750720

SCHEMBL4750720

Nc1cc(Cl)c(Cl)cc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 7/20 0.56
ALDH1A1 P00352 5/20 0.56
HPGD P15428 3/20 0.56
ALOX15 P16050 3/20 0.56
ALOX12 P18054 1/20 0.56
MAPK1 P28482 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
TSHR P16473 6/20 0.55
CYP3A4 P08684 5/20 0.54
GAA P10253 2/20 0.53
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA12 O43570 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA14 Q9ULX7 2/20 0.44
HSP90AA1 P07900 1/20 0.43
THRB P10828 1/20 0.43
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26097641 0.86 HSD17B10 (0.60) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL13331360 0.86 HSD17B10 (0.52) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL18382554 0.86 GAA (0.67) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL29829535 0.86 HSD17B10 (0.52) HSD17B10ALDH1A1HPGDALOX15ALOX12
Hydrochloric Acid SCHEMBL16815459 0.83 ALDH1A1 (0.50) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL11251343 0.81 HSD17B10 (0.44) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL29408803 0.80 GAA (0.67) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL2779101 0.80 GAA (0.67) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL24716192 0.79 ALDH1A1 (0.47) HSD17B10ALDH1A1HPGDALOX15ALOX12
SCHEMBL4544583 0.79 CD44 (0.65) HSD17B10ALDH1A1HPGDALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109053497-B Preparation method and application of hydroxylated triclocarban 香港浸会大学深圳研究院 2021-06-01 CN claimed
JP-54066673-A None JP disclosed
US-20260083721-A1 7-CYANO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF JIANGSU YAHONG MEDITECH CO LTD (CN) 2026-03-26 US disclosed
US-12479807-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2025-11-25 US disclosed
EP-4630412-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD Pharma A/S (DK) 2025-10-15 EP disclosed
EP-4623914-A1 USE OF 8-HYDROXYQUINOLINE DERIVATIVE Jiangsu Yahong Meditech Co., Ltd. (CN) 2025-10-01 EP disclosed
US-RE50527-E1 Covalent inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-08-12 US disclosed
CN-120035438-A Use of 8-hydroxyquinoline derivatives 江苏亚虹医药科技股份有限公司 2025-05-23 CN disclosed
EP-4534530-A1 7-CYANO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Jiangsu Yahong Meditech Co., Ltd. (CN) 2025-04-09 EP disclosed
CN-118679149-A 7-Cyano-8-hydroxyquinoline derivative, preparation method and medical application thereof 江苏亚虹医药科技股份有限公司 2024-09-20 CN disclosed
US-4141890-A FIBER-REACTIVE CIBA-GEIGY CORPORATION (US) 1979-02-27 US disclosed
US-4119634-A BRIGHTENERS FOR PLASTICS AND POLYESTERS BAYER AKTIENGESELLSCHAFT (DE) 1978-10-10 US disclosed
US-4092307-A COPPER, NICKEL, COBALT OR CHROMIUM CIBA-GEIGY CORPORATION (US) 1978-05-30 US disclosed
US-RE29585-E DYEING WOOL CIBA-GEIGY CORPORATION (US) 1978-03-21 US disclosed
US-4067864-A FOR CELLULOSE OR POLYAMIDES CIBA-GEIGY AG (CH) 1978-01-10 US disclosed
US-4039523-A YELLOW CIBA-GEIGY AG (CH) 1977-08-02 US disclosed
US-4017477-A 3-Halogeno-6-hydroxy-pyridone-(2) azo dyestuffs CIBA-GEIGY AG (CH) 1977-04-12 US disclosed
US-3978037-A POLYAMIDES CIBA-GEIGY CORPORATION (US) 1976-08-31 US disclosed
US-3971738-A Heavy metal complexes of azo compounds containing a halogeno-2,3-dihydroxy pyridine coupling component CIBA-GEIGY AG (CH) 1976-07-27 US disclosed
US-3933785-A Azo compounds CIBA-GEIGY AG (CH) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083721-A1 7-CYANO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF HCCS, SLC38A7, HRAS HSD17B10 234/4885ALDH1A1 420/4885HPGD 511/4885
US-12479807-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 HSD17B10 377/4885ALDH1A1 1030/4885HPGD 1412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.