Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747486 | 0.94 | PARP1 (0.58) | GSTO1LMNARAB9ASMN1; SMN2PARP1 | |
| SCHEMBL4747488 | 0.94 | PARP1 (0.58) | GSTO1LMNARAB9ASMN1; SMN2PARP1 | |
| SCHEMBL4747484 | 0.94 | PARP1 (0.58) | GSTO1LMNARAB9ASMN1; SMN2PARP1 | |
| SCHEMBL4746847 | 0.90 | LMNA (0.49) | LMNARAB9ASMN1; SMN2PARP1MAPK1 | |
| SCHEMBL4746820 | 0.88 | L3MBTL1 (0.47) | LMNARAB9APARP1MAPK1KDM4E | |
| SCHEMBL4749915 | 0.85 | MEN1 (0.48) | LMNARAB9ASMN1; SMN2PARP1MAPK1 | |
| SCHEMBL4788679 | 0.83 | SMN1; SMN2 (0.54) | GSTO1LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4750364 | 0.83 | LMNA (0.52) | GSTO1LMNARAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL4750368 | 0.83 | LMNA (0.52) | GSTO1LMNARAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL4750362 | 0.83 | LMNA (0.52) | GSTO1LMNARAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |