Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.64 |
| ▸ | HTR1D known ✓ | P28221 | 2/20 | 0.64 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.64 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.64 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | HTR5A | P47898 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158925 | 0.99 | HTR1A (0.65) | BLMALDH1A1LMNAPMP22HTR1A | |
| SCHEMBL6820459 | 0.99 | HTR1A (0.65) | BLMALDH1A1LMNAPMP22HTR1A | |
| SCHEMBL7023248 | 0.99 | HTR1A (0.65) | BLMALDH1A1LMNAPMP22HTR1A | |
| SCHEMBL3736504 | 0.89 | DRD2 (0.79) | BLMALDH1A1LMNAPMP22HTR1A | |
| SCHEMBL7024427 | 0.88 | DRD2 (0.68) | LMNAPMP22HTR1AHTR7DRD2 | |
| SCHEMBL7029720 | 0.88 | DRD2 (0.68) | LMNAPMP22HTR1AHTR7DRD2 | |
| SCHEMBL841913 | 0.82 | DRD2 (0.51) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL841912 | 0.82 | DRD2 (0.51) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL6820475 | 0.82 | DRD2 (0.51) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL841199 | 0.82 | DRD2 (0.51) | HTR1AHTR7DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |