Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MPI | P34949 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753342 | 0.86 | MAPT (0.49) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4751026 | 0.82 | MAPT (0.41) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4751000 | 0.82 | ALDH1A1 (0.48) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4750973 | 0.82 | MAPT (0.45) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4754202 | 0.81 | MAPT (0.44) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4750763 | 0.81 | ADORA3 (0.44) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4753314 | 0.80 | NPSR1 (0.46) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4751015 | 0.79 | MAPT (0.43) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4751031 | 0.79 | POLB (0.49) | MAPTKMT2AMPIHTTMEN1 | |
| SCHEMBL4750997 | 0.79 | MAPT (0.42) | MAPTKMT2AMPIHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |
| WO-2007109324-A2 | POTENT AND SELECTIVE NAV 1.7 SODIUM CHANNEL BLOCKERS | XENON PHARMACEUTICALS, INC. (CA) | 2007-09-27 | — | — | WO | disclosed |