Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751312 | 0.83 | POLB (0.55) | NR4A2MAPTGAAATMCYP1A2 | |
| Metaquine SCHEMBL7205743 | 0.80 | FADS1 (0.71) | FADS1APPNR4A2MAPTGAA | |
| SCHEMBL5309628 | 0.77 | MAPT (0.74) | FADS1APPNR4A2MAPTGAA | |
| SCHEMBL29950963 | 0.77 | GAA (0.65) | APPNR4A2MAPTGAAATM | |
| SCHEMBL5591942 | 0.76 | GRM4 (0.47) | NR4A2MAPTCYP1A2POLBKMT2A | |
| SCHEMBL9482173 | 0.74 | MAPT (0.69) | APPNR4A2MAPTGAAATM | |
| SCHEMBL2011565 | 0.74 | GAA (0.73) | FADS1APPNR4A2MAPTGAA | |
| SCHEMBL30179800 | 0.74 | GAA (0.73) | FADS1APPNR4A2MAPTGAA | |
| SCHEMBL19633680 | 0.74 | FADS1 (0.63) | FADS1APPNR4A2MAPTGAA | |
| SCHEMBL5257871 | 0.74 | KDR (0.81) | FADS1APPNR4A2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135886-A2 | QUINOLINE DERIVATIVES FOR USE IN THE INHIBITION OF THE GROWTH OF TUMOUR CELLS | UNIVERSITY OF PRETORIA (ZA) | 2008-11-13 | — | — | WO | disclosed |