Metaquine

Metaquine

SCHEMBL7205743

Clc1ccc2c(Nc3cccc(Nc4ccnc5cc(Cl)ccc45)c3)ccnc2c1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FADS1 O60427 1/20 0.71
MAPT P10636 3/20 0.69
GAA P10253 1/20 0.69
ATM Q13315 1/20 0.69
APP P05067 2/20 0.67
NR4A2 P43354 2/20 0.67
KMT2A Q03164 2/20 0.61
TDP1 Q9NUW8 2/20 0.61
GAK O14976 1/20 0.61
CYP1A2 P05177 5/20 0.61
CYP2D6 P10635 4/20 0.61
MEN1 O00255 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
CCR1 P32246 1/20 0.57
CA9 Q16790 1/20 0.57
CYP2C8 P10632 3/20 0.57
CYP2C19 P33261 3/20 0.57
CYP2C9 P11712 2/20 0.57
POLB P06746 1/20 0.56
THRB P10828 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5309628 0.91 MAPT (0.74) FADS1MAPTGAAATMAPP
SCHEMBL30179800 0.90 GAA (0.73) FADS1MAPTGAAATMAPP
SCHEMBL2011565 0.90 GAA (0.73) FADS1MAPTGAAATMAPP
SCHEMBL19633680 0.90 FADS1 (0.63) FADS1MAPTGAAATMAPP
SCHEMBL19633693 0.87 GAK (0.65) FADS1MAPTGAAATMAPP
SCHEMBL21121890 0.87 FADS1 (0.59) FADS1MAPTGAAATMAPP
SCHEMBL21346892 0.87 FADS1 (0.59) FADS1MAPTGAAATMAPP
SCHEMBL4751748 0.87 APP (0.70) FADS1MAPTGAAATMAPP
SCHEMBL21346925 0.86 CYP1A2 (0.66) FADS1MAPTGAAATMAPP
SCHEMBL31020175 0.85 MAPT (0.63) FADS1MAPTGAAATMAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0765313-B1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS HOFFMANN LA ROCHE (CH) 2003-08-20 EP claimed
EP-0765313-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F. HOFFMANN-LA ROCHE AG (CH) 1997-04-02 EP claimed
WO-1995035287-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F.HOFFMANN-LA ROCHE AG (CH) 1995-12-28 WO claimed
CN-115515702-A Method and device for influencing entities in a gas flow 菲尔特森 2022-12-23 CN disclosed
EP-0765313-B1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS HOFFMANN LA ROCHE (CH) 2003-08-20 EP disclosed
US-5736557-A MICROBIOCIDE EFFECTIVE AGAINST CHLOROQUINE-RESISTANT AND CHLOROQUINE-SENSITIVE STRAINS OF PLASMODIUM FALCIPARUM HOFFMAN-LA ROCHE, INC. (US) 1998-04-07 US disclosed
EP-0765313-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F. HOFFMANN-LA ROCHE AG (CH) 1997-04-02 EP disclosed
WO-1995035287-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F.HOFFMANN-LA ROCHE AG (CH) 1995-12-28 WO disclosed