Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721049 | 1.00 | KMT2A (0.47) | KMT2AKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4026560 | 0.87 | RORC (0.43) | KMT2AALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL4021398 | 0.87 | KDM2B (0.45) | KMT2AALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL4024597 | 0.87 | KDM2B (0.45) | KMT2AALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL4751581 | 0.85 | KMT2A (0.46) | KMT2AKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4751579 | 0.85 | KMT2A (0.46) | KMT2AKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4751582 | 0.85 | KMT2A (0.46) | KMT2AKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4018783 | 0.85 | KDM2B (0.43) | KMT2AALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL13721307 | 0.85 | KDM2B (0.43) | KMT2AALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL4027956 | 0.85 | KDM2B (0.43) | KMT2AALDH1A1HTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |