Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.66 |
| ▸ | PDE4A | P27815 | 3/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751642 | 1.00 | PDE5A (0.66) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL149367 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL149365 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL149366 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL2436275 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL233525 | 0.64 | PDE5A (0.45) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL24486041 | 0.58 | GPR84 (0.41) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL236619 | 0.57 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL236618 | 0.57 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL236620 | 0.57 | PDE5A (1.00) | PDE5APDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135824-A1 | OXYALKYLPYRAZOLE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |