Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751690 | 1.00 | ADRB2 (0.34) | ADRB2ADRB1ADRB3DRD2DRD3 | |
| SCHEMBL4751841 | 0.91 | DRD3 (0.34) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4751833 | 0.91 | DRD3 (0.34) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749510 | 0.89 | DRD3 (0.34) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749471 | 0.89 | DRD3 (0.34) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4752868 | 0.88 | DRD2 (0.33) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749501 | 0.88 | DRD3 (0.33) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749151 | 0.88 | DRD3 (0.33) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749235 | 0.88 | DRD3 (0.35) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL4749174 | 0.88 | DRD2 (0.33) | DRD2DRD3HTR1ADRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |