Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751369 | 0.94 | MC4R (0.42) | MC4RRAB9ARBP4KMT2AGSK3B | |
| SCHEMBL4751347 | 0.90 | MC4R (0.44) | MC4RRBP4KMT2ANTRK1ALDH1A1 | |
| SCHEMBL4752746 | 0.90 | MC4R (0.44) | MC4RRBP4KMT2AGSK3BNTRK1 | |
| SCHEMBL4776650 | 0.89 | MC4R (0.44) | MC4RRBP4KMT2ANTRK1ALDH1A1 | |
| SCHEMBL4776626 | 0.89 | MC4R (0.44) | MC4RRBP4KMT2ANTRK1DRD3 | |
| SCHEMBL4751319 | 0.88 | MC4R (0.41) | MC4RRBP4KMT2ANTRK1ALDH1A1 | |
| SCHEMBL4794920 | 0.88 | MC4R (0.44) | MC4RRBP4KMT2ANTRK1ALDH1A1 | |
| SCHEMBL4774717 | 0.87 | MC4R (0.43) | MC4RKMT2ANTRK1ALDH1A1 | |
| SCHEMBL4751666 | 0.87 | MC4R (0.43) | MC4RRBP4KMT2ANTRK1 | |
| SCHEMBL4752905 | 0.87 | MC4R (0.43) | MC4RRBP4KMT2ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |