Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.47 |
| ▸ | CDK2 | P24941 | 10/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.47 |
| ▸ | CDK4 | P11802 | 5/20 | 0.47 |
| ▸ | CCND3 | P30281 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK14 | O94921 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022861 | 0.87 | CCNA2 (0.52) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL14023924 | 0.87 | CCNA2 (0.47) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL4749275 | 0.82 | ABL1 (0.39) | SYK | |
| SCHEMBL4752216 | 0.82 | IGF1R (0.39) | CDK2SYK | |
| SCHEMBL4813575 | 0.79 | EGFR (0.37) | — | |
| SCHEMBL31679503 | 0.75 | JAK3 (0.51) | CCND3CDK6NTRK3 | |
| SCHEMBL4752976 | 0.72 | AXL (0.46) | CDK2CDK4SYKCDK14FLT3 | |
| SCHEMBL14023524 | 0.72 | RET (0.38) | CDK2MTORSYKCDK1CCNB1 | |
| SCHEMBL4751809 | 0.71 | ABL1 (0.42) | SYK | |
| SCHEMBL824059 | 0.71 | MAPT (0.45) | CDK2CDK4GSK3BMTORCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |