⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980126 | 0.79 | — | — | |
| SCHEMBL12352066 | 0.79 | — | — | |
| SCHEMBL26658795 | 0.75 | — | — | |
| SCHEMBL21737363 | 0.75 | — | — | |
| SCHEMBL29144926 | 0.75 | — | — | |
| SCHEMBL24225498 | 0.72 | NUDT1 (0.34) | — | |
| SCHEMBL25928370 | 0.72 | APLNR (0.33) | — | |
| SCHEMBL26860463 | 0.72 | HPGD (0.33) | — | |
| SCHEMBL26860462 | 0.72 | TDP1 (0.31) | — | |
| SCHEMBL25928373 | 0.72 | CCR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025264278-A1 | ERK2 DEGRADERS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2025-12-26 | — | — | WO | disclosed |
| WO-2024233665-A1 | COMPOUNDS AND THEIR USE AGAINST CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-11-14 | — | — | WO | disclosed |
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-25 | — | — | US | disclosed |
| US-9422271-B2 | Pyrimidine compounds as tuberculosis inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-08-23 | — | — | US | disclosed |
| US-20140249137-A1 | PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-04 | — | — | US | disclosed |
| US-20110053916-A1 | PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-03 | — | — | US | disclosed |
| WO-2008147831-A1 | ANTHRANILAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008147831-A1 | ANTHRANILAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-04 | — | — | WO | disclosed |