Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982544 | 0.87 | NPSR1 (0.42) | NPSR1PKMFAAHMAPTRAB9A | |
| SCHEMBL4753314 | 0.85 | NPSR1 (0.46) | NPSR1PKMFAAHMAPTRAB9A | |
| SCHEMBL4751031 | 0.85 | POLB (0.49) | NPSR1MAPTRAB9ANPC1KDM4E | |
| SCHEMBL4753342 | 0.82 | MAPT (0.49) | NPSR1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4754202 | 0.82 | MAPT (0.44) | NPSR1MAPTRAB9ANPC1KDM4E | |
| SCHEMBL4750973 | 0.80 | MAPT (0.45) | NPSR1PKMMAPTRAB9ANPC1 | |
| SCHEMBL4750763 | 0.80 | ADORA3 (0.44) | NPSR1FAAHMAPTRAB9ANPC1 | |
| SCHEMBL13982676 | 0.80 | TSHR (0.50) | MAPTNPC1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL13982765 | 0.80 | EPHX2 (0.45) | SMN1; SMN2KDM4ETSHRHTT | |
| SCHEMBL4751010 | 0.78 | MAPT (0.44) | NPSR1MAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |