Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752858 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL4752859 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1645674 | 0.98 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1645672 | 0.98 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1645718 | 0.94 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL6229240 | 0.89 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1347306 | 0.87 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1347312 | 0.87 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1347304 | 0.87 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 | |
| SCHEMBL1347308 | 0.87 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNB3CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157365-A2 | VINYLAZACYCLOALKANES FOR TREATING NEUROPATHIC PAIN | TARGACEPT, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| US-20060094732-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | SCHMITT JEFFREY D | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094732-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | CHRNA5, OPRK1, CHRNA6 | CHRNB2 7/4885CHRNB4 15/4885CHRNA3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.