Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108678 | 0.90 | KDM4E (0.70) | MEN1KMT2ACYP2D6KDM4EUSP2 | |
| SCHEMBL2316901 | 0.86 | CYP2D6 (0.82) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL19300185 | 0.86 | CYP2D6 (0.63) | MEN1KMT2ACYP2D6KDM4EUSP2 | |
| SCHEMBL8170046 | 0.83 | KDM4E (0.62) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL19300219 | 0.83 | KDM4E (0.62) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL2056152 | 0.83 | KDM4E (0.62) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL8286300 | 0.83 | KDM4E (0.62) | MEN1KMT2ACYP2D6KDM4EUSP2 | |
| SCHEMBL22005473 | 0.83 | KDM4E (0.62) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL13062752 | 0.83 | ALDH1A1 (0.64) | MEN1KMT2ACYP2D6ALDH1A1KDM4E | |
| SCHEMBL6482711 | 0.82 | MEN1 (0.61) | MEN1KMT2ACYP2D6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |