Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170046 | 0.93 | KDM4E (0.62) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL8286300 | 0.92 | KDM4E (0.62) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL19300185 | 0.92 | CYP2D6 (0.63) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL22005473 | 0.92 | KDM4E (0.62) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL2316901 | 0.92 | CYP2D6 (0.82) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL19300219 | 0.92 | KDM4E (0.62) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL2056152 | 0.92 | KDM4E (0.62) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL13062752 | 0.92 | ALDH1A1 (0.64) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL6482711 | 0.91 | MEN1 (0.61) | KDM4ECYP2D6MEN1USP2CYP1A2 | |
| SCHEMBL4753138 | 0.90 | MEN1 (0.66) | KDM4ECYP2D6MEN1USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4264770-A | Process for preparing 1,4-bis-piperonylpiperazine and similar compounds | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1981-04-28 | — | — | US | claimed |
| US-4225714-A | Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1980-09-30 | — | — | US | claimed |
| US-10435394-B2 | Plant growth-promotion agent and method for promoting plant growth | RIKEN (JP) | 2019-10-08 | — | — | US | disclosed |
| US-10435394-B2 | Plant growth-promotion agent and method for promoting plant growth | RIKEN (JP) | 2019-10-08 | — | — | US | disclosed |
| US-20170305886-A1 | PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH | RIKEN (JP) | 2017-10-26 | — | — | US | disclosed |
| US-20170305886-A1 | PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH | RIKEN (JP) | 2017-10-26 | — | — | US | disclosed |
| US-20170305886-A1 | PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH | RIKEN (JP) | 2017-10-26 | — | — | US | disclosed |
| US-9051253-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's | PROTEOTECH INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-9051253-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's | PROTEOTECH INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-9051253-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's | PROTEOTECH INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-8895554-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease | PROTEOTECH INC (US) | 2014-11-25 | — | — | US | disclosed |
| EP-1511710-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER S DISEASE, TYPE 2 DIABETES, AND PARKINSON S DISEASE | Proteotech, Inc. (US) | 2005-03-09 | — | — | EP | disclosed |
| US-20040127555-A1 | bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs; treatment of A beta , IAPP, other amyloids, and alpha -synuclein or NAC fibrillogenesis | PROTAMED, INC. | 2004-07-01 | — | — | US | disclosed |
| WO-2003101927-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE | PROTEOTECH, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
| WO-2003101927-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE | PROTEOTECH, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
| US-4264770-A | Process for preparing 1,4-bis-piperonylpiperazine and similar compounds | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1981-04-28 | — | — | US | disclosed |
| US-4264770-A | Process for preparing 1,4-bis-piperonylpiperazine and similar compounds | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1981-04-28 | — | — | US | disclosed |
| US-4264770-A | Process for preparing 1,4-bis-piperonylpiperazine and similar compounds | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1981-04-28 | — | — | US | disclosed |
| US-4225714-A | Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1980-09-30 | — | — | US | disclosed |
| US-4225714-A | Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1980-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435394-B2 | Plant growth-promotion agent and method for promoting plant growth | NPR1, NAT1, NOS1 | KDM4E 3307/4885CYP2D6 4522/4885MEN1 1168/4885 |
| US-20040127555-A1 | bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs; treatment of A beta , IAPP, other amyloids, and alpha -synuclein or NAC fibrillogenesis | IAPP, SNCA, IDE | KDM4E 4549/4885CYP2D6 2754/4885MEN1 3591/4885 |
| US-20170305886-A1 | PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH | NPR1, NAT1, NOS1 | KDM4E 3307/4885CYP2D6 4522/4885MEN1 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.