Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379941 | 0.83 | NPC1 (0.42) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1619231 | 0.76 | MAPT (0.42) | ALDH1A1CETPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2379132 | 0.73 | HDAC3 (0.42) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL4041375 | 0.73 | MAPT (0.41) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14023387 | 0.73 | GSK3B (0.48) | KMT2ACETPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2380242 | 0.72 | TRPV1 (0.38) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4036061 | 0.71 | CETP (0.39) | CETPNPC1RAB9AMAPT | |
| SCHEMBL2379221 | 0.70 | MAPT (0.46) | MEN1KMT2AALDH1A1CETPSMN1; SMN2 | |
| SCHEMBL4749788 | 0.70 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1CETPSMN1; SMN2 | |
| SCHEMBL1619230 | 0.70 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1CETPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141077-A1 | PROCESS FOR THE PREPARATION OF TETRAHYDROQUINOLINYL, BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-20 | — | — | WO | disclosed |