Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | COMT | P21964 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12751498 | 0.81 | MAPT (0.41) | MAPTPAX8SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4749788 | 0.80 | ALDH1A1 (0.45) | MAPTPAX8SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1619230 | 0.80 | ALDH1A1 (0.45) | MAPTPAX8SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4753149 | 0.76 | MEN1 (0.44) | MAPTSMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL29972895 | 0.70 | MAPT (0.58) | MAPTSMN1; SMN2ALDH1A1LMNAATM | |
| SCHEMBL23609099 | 0.68 | RAB9A (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAATM | |
| SCHEMBL28852575 | 0.68 | RAB9A (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAATM | |
| SCHEMBL978712 | 0.67 | AKR1C3 (0.54) | MAPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL14305995 | 0.66 | MAOB (0.67) | MAPTPAX8SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4041375 | 0.66 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928238-B2 | 1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-19 | — | — | US | disclosed |