Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15391489 | 0.81 | LMNA (0.73) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL13734448 | 0.79 | LMNA (0.59) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL13732783 | 0.76 | NPC1 (0.61) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL13734349 | 0.76 | NPC1 (0.61) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL899466 | 0.76 | ALDH1A1 (0.62) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL13734751 | 0.75 | LMNA (0.59) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL13734464 | 0.75 | LMNA (0.59) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL1432330 | 0.75 | SMN1; SMN2 (0.72) | POLBHTTSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL13736715 | 0.74 | ALDH1A1 (0.76) | POLBHTTSMN1; SMN2USP2KMT2A | |
| SCHEMBL899616 | 0.74 | TSHR (0.66) | POLBHTTSMN1; SMN2USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |