Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754259 | 0.81 | P2RX7 (0.62) | P2RX7 | |
| SCHEMBL4756363 | 0.80 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL3590096 | 0.78 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL4696025 | 0.75 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL4750584 | 0.75 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL4696530 | 0.74 | P2RX7 (0.58) | P2RX7 | |
| SCHEMBL3292577 | 0.74 | P2RX7 (0.74) | P2RX7 | |
| SCHEMBL10616320 | 0.72 | PTGS1 (0.52) | P2RX7 | |
| SCHEMBL11094559 | 0.72 | PTGS1 (0.45) | P2RX7 | |
| SCHEMBL10850615 | 0.71 | P2RX7 (0.36) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963275-A2 | P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | Abbott Laboratories (US) | 2008-09-03 | — | — | EP | claimed |
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | claimed |
| WO-2007056091-A2 | 2-PHENYL-2H-PYRAZ0LE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-05-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259920-A1 | P2X7, receptor antagonists and uses thereof | P2RX7, P2RX1, P2RX3 | P2RX7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.