Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16475309 | 0.84 | ALDH1A1 (0.56) | AURKAPDPK1TGFBR1AURKBKDM4E | |
| SCHEMBL16475312 | 0.78 | ADORA1 (0.51) | ADORA2AAURKAPDPK1TGFBR1AURKB | |
| SCHEMBL13329282 | 0.78 | KMT2A (0.46) | ADORA2AAURKAPDPK1TGFBR1AURKB | |
| SCHEMBL3393329 | 0.78 | HPGD (0.44) | CHUKADORA2ANUDT1ADORA1KDM4E | |
| SCHEMBL8402104 | 0.76 | BTK (0.58) | BTKPIK3CG | |
| SCHEMBL18040266 | 0.75 | DPP4 (0.49) | ADORA2AADORA1KDM4EALDH1A1KMT2A | |
| SCHEMBL16475314 | 0.75 | BTK (0.36) | ADORA2AAURKAAURKBADORA1KDM4E | |
| SCHEMBL3716787 | 0.75 | NPC1 (0.46) | ADORA2AADORA1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6115757 | 0.74 | BTK (0.67) | ADORA2AAURKAPDPK1TGFBR1AURKB | |
| SCHEMBL13329310 | 0.74 | LMNA (0.48) | ADORA2AKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926734-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | Amgen Inc. (US) | 2008-06-04 | — | — | EP | claimed |
| WO-2007024680-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | AMGEN INC. (US) | 2007-03-01 | — | — | WO | claimed |