Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.44 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756452 | 0.79 | SQSTM1 (0.48) | DHFRSQSTM1NEK2 | |
| SCHEMBL4755174 | 0.76 | SQSTM1 (0.48) | DHFRSQSTM1NEK2 | |
| SCHEMBL4753525 | 0.74 | DHFR (0.46) | DHFRNEK2KDM4EALDH1A1HPGD | |
| SCHEMBL4753726 | 0.73 | SMN1; SMN2 (0.45) | DHFRSMN1; SMN2 | |
| SCHEMBL4754987 | 0.73 | SQSTM1 (0.45) | DHFRSQSTM1NEK2 | |
| SCHEMBL4753592 | 0.71 | DHFR (0.47) | DHFRSQSTM1 | |
| SCHEMBL4756475 | 0.69 | DHFR (0.49) | DHFRSQSTM1 | |
| SCHEMBL4753839 | 0.69 | DHFR (0.50) | DHFRSQSTM1SMN1; SMN2 | |
| SCHEMBL6750818 | 0.69 | DHODH (0.45) | DHFRSQSTM1 | |
| SCHEMBL4753723 | 0.67 | NEK2 (0.51) | DHFRNEK2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |