Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499700 | 0.83 | MAPT (0.44) | MAPTKDM4EAOC3HTR3EHTR3B | |
| SCHEMBL4753581 | 0.81 | TMEM97 (0.45) | MAPTKDM4ETMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL11133767 | 0.71 | MAPT (0.65) | MAPTKDM4EAOC3HTR3EHTR3B | |
| SCHEMBL18300919 | 0.69 | CRHBP (0.52) | AOC3ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL2096198 | 0.69 | HTR3E (0.61) | MAPTKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL31715773 | 0.69 | HTR3E (0.61) | MAPTKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL1937726 | 0.68 | — | — | |
| SCHEMBL11793760 | 0.68 | TAAR1 (0.44) | MAPTADRA2CSIGMAR1ALDH1A1HTT | |
| SCHEMBL342097 | 0.68 | MAPT (0.55) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL8378174 | 0.68 | MAPT (0.48) | MAPTKDM4EHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |