Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852832 | 0.85 | ELANE (0.53) | ELANEF2PLAUACHE | |
| SCHEMBL5109043 | 0.84 | ELANE (0.48) | ELANEF2PLAUACHEBCHE | |
| SCHEMBL9467082 | 0.84 | ELANE (0.48) | ELANEF2PLAUACHEBCHE | |
| SCHEMBL5120293 | 0.81 | ELANE (0.56) | ELANEF2PLAU | |
| SCHEMBL9987666 | 0.80 | ELANE (0.55) | ELANEF2PLAU | |
| SCHEMBL9646820 | 0.79 | ELANE (0.45) | ELANEF2PLAU | |
| SCHEMBL9647806 | 0.79 | ELANE (0.45) | ELANEF2PLAUACHEBCHE | |
| SCHEMBL5120296 | 0.79 | ELANE (0.56) | ELANEF2PLAU | |
| SCHEMBL9647055 | 0.78 | ELANE (0.43) | ELANEF2PLAUACHEBCHE | |
| SCHEMBL9647897 | 0.78 | GABRA1 (0.51) | ELANEF2PLAUACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960355-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007062996-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |