Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120293 | 0.86 | ELANE (0.56) | ELANEF2PLAU | |
| SCHEMBL5120296 | 0.83 | ELANE (0.56) | ELANEF2PLAU | |
| SCHEMBL517483 | 0.82 | ELANE (0.55) | ELANEF2PLAU | |
| SCHEMBL2674135 | 0.81 | MAP2K4 (0.44) | ELANEF2PLAU | |
| SCHEMBL6852832 | 0.81 | ELANE (0.53) | ELANEF2PLAU | |
| SCHEMBL4753928 | 0.80 | ELANE (0.50) | ELANEF2PLAU | |
| SCHEMBL11753223 | 0.79 | ELANE (0.52) | ELANEF2PLAU | |
| SCHEMBL5583818 | 0.79 | ELANE (0.54) | ELANEF2PLAU | |
| SCHEMBL25769987 | 0.77 | ELANE (0.40) | ELANEF2PLAU | |
| SCHEMBL5109043 | 0.75 | ELANE (0.48) | ELANEF2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2584903-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163330-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-29 | — | — | WO | disclosed |