SCHEMBL1193735

SCHEMBL1193735

O=c1cc(O)c2ccccc2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 1.00
ALDH1A1 P00352 5/20 1.00
CYP1A2 P05177 1/20 0.62
CYP2C19 P33261 1/20 0.62
TNKS2 Q9H2K2 1/20 0.62
HPGD P15428 3/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
HTT P42858 2/20 0.58
MAPK1 P28482 1/20 0.58
KDM5A P29375 1/20 0.58
MAPT P10636 1/20 0.52
IDE P14735 1/20 0.52
MPI P34949 1/20 0.52
CACNA1B Q00975 1/20 0.52
APBA1 Q02410 1/20 0.52
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
GAA P10253 2/20 0.50
LMNA P02545 1/20 0.50
GLA P06280 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29624606 1.00 KDM4E (1.00) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
Carbamic Acid SCHEMBL27445664 0.91 KDM4E (0.83) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL9388988 0.88 KDM4E (0.79) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL30430848 0.80 ALDH1A1 (0.67) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
L-Threonic Acid SCHEMBL22469954 0.80 KDM4E (0.63) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL9724160 0.78 KDM4E (0.64) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL27775921 0.77 KDM4E (0.62) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL29650180 0.77 TNKS2 (1.00) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL377796 0.77 TNKS2 (1.00) KDM4EALDH1A1CYP1A2CYP2C19TNKS2
SCHEMBL1771514 0.76 CYP1A2 (0.63) KDM4EALDH1A1CYP1A2CYP2C19TNKS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 744 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114891011-B Preparation method of medical intermediate 2-amino-tetrahydropyran [3,2-c ] quinoline-5-one derivative 南京苏亦欣医药科技有限公司 2025-01-17 CN claimed
CN-108218882-B Pyrano [2,3-b ] quinoline derivative, preparation method and application thereof in antitumor aspect 精华制药集团南通有限公司 2021-11-23 CN claimed
CN-113416166-A Method for preparing 4-hydroxyquinoline-2 (1H) -ketone compound 浙江外国语学院 2021-09-21 CN claimed
CN-110041306-A 4- hydroxyl -2- quinolone-nitrogen-(4- quinazolinone) -3- carboxamides derivatives 中国医学科学院药物研究所 2019-07-23 CN claimed
EP-2182914-B1 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF L'ORÉAL (FR) 2017-11-08 EP claimed
EP-3102195-A1 BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS Quadriga Biosciences, Inc. (US) 2016-12-14 EP claimed
EP-3102194-A1 BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS Quadriga Biosciences, Inc. (US) 2016-12-14 EP claimed
CN-103508950-B Containing 4-hydroxyl-2-quinolinones compound and the Synthesis and applications thereof of imine structure NANKAI UNIVERSITY (CN) 2016-04-20 CN claimed
WO-2015117147-A1 BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS QUADRIGA BIOSCIENCES, INC. (US) 2015-08-06 WO claimed
WO-2015117146-A1 BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS QUADRIGA BIOSCIENCES, INC. (US) 2015-08-06 WO claimed
WO-1998023690-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1998-06-04 WO claimed
EP-0605566-A1 LIGHT-ABSORBING POLYURETHANE COMPOSITIONS AND THERMOPLASTIC POLYMERS COLORED THEREWITH EASTMAN CHEMICAL COMPANY (US) 1994-07-13 EP claimed
WO-1993006147-A1 LIGHT-ABSORBING POLYURETHANE COMPOSITIONS AND THERMOPLASTIC POLYMERS COLORED THEREWITH EASTMAN KODAK COMPANY (US) 1993-04-01 WO claimed
US-5194463-A LIGHT-ABSORBING POLYURETHANE COMPOSITIONS AND THERMOPLASTIC POLYMERS COLORED THEREWITH EASTMAN KODAK COMPANY (US) 1993-03-16 US claimed
US-5061605-A IMPROVED SENSITIVITY TO LONG WAVELENGTHS FUJI PHOTO FILM CO., LTD. (JP) 1991-10-29 US claimed
EP-0101330-B1 2-QUINOLONE DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1988-08-24 EP claimed
EP-0062001-B1 ACYL QUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE CIBA-GEIGY AG (CH) 1987-05-27 EP claimed
EP-0101330-A2 2-Quinolone derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1984-02-22 EP claimed
EP-0062001-A2 Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use CIBA-GEIGY AG (CH) 1982-10-06 EP claimed
US-3979320-A Liquid crystal composition HODOGAYA CHEMICAL CO., LTD. (JA) 1976-09-07 US claimed