Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1249230 | 0.81 | MAPT (0.66) | SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8421926 | 0.81 | MAPT (0.65) | HPGDHTTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL30172106 | 0.79 | PKM (0.56) | TSHRSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2528973 | 0.79 | PLK1 (1.00) | PLK1HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL14341662 | 0.77 | PLK1 (0.71) | PLK1HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL27423425 | 0.77 | PLK1 (0.71) | PLK1HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL27316975 | 0.77 | PARP10 (0.59) | ALDH1A1 | |
| SCHEMBL4751948 | 0.76 | PLK1 (0.69) | PLK1HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL12839873 | 0.76 | PLK1 (0.87) | PLK1HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL11962158 | 0.76 | PLK1 (1.00) | PLK1HPGDTSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |