Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355261 | 0.87 | CACNA1G (0.67) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL11460456 | 0.86 | IGF1R (0.70) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL13875132 | 0.85 | IGF1R (0.65) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL8576435 | 0.82 | IGF1R (0.65) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL11465764 | 0.82 | IGF1R (0.65) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL2017995 | 0.81 | MAPT (0.74) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL2017996 | 0.81 | MAPT (0.74) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL2017993 | 0.81 | MAPT (0.74) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL11723131 | 0.80 | IGF1R (0.57) | GAAMAPTLMNASMN1; SMN2HSD17B10 | |
| SCHEMBL4037828 | 0.78 | IGF1R (0.60) | GAAMAPTLMNASMN1; SMN2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |