Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11284379 | 0.86 | IGF1R (0.60) | IGF1RALDH1A1MAPTSIGMAR1GAA | |
| Hydrochloric Acid SCHEMBL8576435 | 0.85 | IGF1R (0.65) | IGF1RALDH1A1MAPTSIGMAR1GAA | |
| SCHEMBL8159579 | 0.84 | SIGMAR1 (0.64) | IGF1RALDH1A1MAPTSIGMAR1MAPK1 | |
| SCHEMBL11460456 | 0.83 | IGF1R (0.70) | IGF1RALDH1A1MAPTSIGMAR1GAA | |
| SCHEMBL13875132 | 0.83 | IGF1R (0.65) | IGF1RALDH1A1MAPTSIGMAR1GAA | |
| SCHEMBL6926448 | 0.81 | SIGMAR1 (0.64) | ALDH1A1MAPTSIGMAR1GAAMAPK1 | |
| SCHEMBL13995622 | 0.81 | SIGMAR1 (0.64) | ALDH1A1MAPTSIGMAR1MAPK1MEN1 | |
| SCHEMBL11453795 | 0.81 | IGF1R (0.67) | IGF1RALDH1A1MAPTSIGMAR1GAA | |
| SCHEMBL28226906 | 0.81 | ALDH1A1 (0.77) | ALDH1A1MAPTSIGMAR1MAPK1MEN1 | |
| SCHEMBL11465764 | 0.80 | IGF1R (0.65) | IGF1RALDH1A1MAPTSIGMAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1764134-B1 | Purine derivatives linked to arylpiperazines | SPECTRUM PHARMACEUTICALS INC (US) | 2009-01-28 | — | — | EP | disclosed |
| EP-1412028-B1 | TETRAHYDROINDOLONE DERIVATIVES LINKED TO ARYLPIPERAZINES | SPECTRUM PHARMACEUTICALS INC (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1764134-A2 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | Spectrum Pharmaceuticals, Inc. (US) | 2007-03-21 | — | — | EP | disclosed |
| US-6770638-B2 | PSYCHOLOGICAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS | SPECTRUM PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| EP-1412028-A1 | TETRAHYDROINDOLONE AND PURINE DERIVATIVES LINKED TO ARYLPIPERAZINES | Neotherapeutics, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| US-20030114463-A1 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | SPECTRUM PHARMACEUTICALS, INC. | 2003-06-19 | — | — | US | disclosed |
| WO-2003011396-A1 | TETRAHYDROINDOLONE AND PURINE DERIVATIVES LINKED TO ARYLPIPERAZINES | NEOTHERAPEUTICS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114463-A1 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | HTR5A, GABRA5, HTR2C | IGF1R 4543/4885ALDH1A1 1880/4885MAPT 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.