Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | CTSA | P10619 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29784182 | 0.83 | SCN9A (0.56) | SCN9ACYP2C9CYP3A4CYP2D6FFAR1 | |
| SCHEMBL1400067 | 0.83 | SCN9A (0.56) | SCN9ACYP2C9CYP3A4CYP2D6FFAR1 | |
| SCHEMBL14564399 | 0.83 | SCN9A (0.51) | SCN9ACYP2C9CYP3A4CYP2D6FFAR1 | |
| SCHEMBL4507814 | 0.82 | SCN9A (0.55) | SCN9ACYP2C9CYP3A4CYP2D6SCN10A | |
| SCHEMBL1400209 | 0.82 | SCN9A (0.65) | SCN9ACYP2C9CYP3A4CYP2D6SCN10A | |
| SCHEMBL1400086 | 0.82 | SCN9A (0.57) | SCN9ACYP2C9CYP3A4CYP2D6FFAR1 | |
| SCHEMBL4499621 | 0.81 | SCN9A (0.50) | SCN9ACYP2C9CYP3A4CYP2D6FFAR1 | |
| SCHEMBL1400239 | 0.80 | SCN9A (0.58) | SCN9ACYP2C9CYP3A4CYP2D6CTSA | |
| SCHEMBL311472 | 0.76 | KAT6A (0.52) | — | |
| SCHEMBL29393449 | 0.76 | KAT6A (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618099-A4 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO INC (US) | 2008-07-16 | — | — | EP | disclosed |
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
| EP-1618099-A2 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | Merck & Co., Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094395-A2 | BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | TRPV1, TRPA1, TRPV3 | SCN9A 70/4885CYP2C9 1715/4885CYP3A4 1979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.