SCHEMBL4754828

SCHEMBL4754828

N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CC(=O)NN)c2F)c1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.51
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 1/20 0.45
KCNH2 Q12809 4/20 0.38
RORC P51449 1/20 0.36
ALDH1A1 P00352 2/20 0.34
HTR2A P28223 2/20 0.34
MAPT P10636 1/20 0.34
IDO1 P14902 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
VEGFA P15692 2/20 0.34
EPAS1 Q99814 2/20 0.34
MEP1B Q16820 1/20 0.34
ERCC1 P07992 1/20 0.33
ERCC4 Q92889 1/20 0.33
POLB P06746 1/20 0.33
EPHX2 P34913 1/20 0.33
SLC6A4 P31645 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4754790 0.90 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL3220100 0.88 CYP3A4 (0.54) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL1343826 0.87 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL1344613 0.87 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL2638669 0.85 CYP3A4 (0.48) CYP3A4CYP2C9CYP2C19RORCALDH1A1
SCHEMBL4752685 0.84 MEP1B (0.38) CYP3A4CYP2C9CYP2C19ALDH1A1MAPT
SCHEMBL13586458 0.83 CYP3A4 (0.48) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL13983342 0.82 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19KCNH2RORC
SCHEMBL3022570 0.82 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19KCNH2HTR2A
SCHEMBL3914677 0.82 CYP3A4 (0.46) CYP3A4CYP2C9CYP2C19KCNH2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008157330-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-24 WO disclosed
WO-2008157330-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-24 WO disclosed
WO-2008157273-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-24 WO disclosed
WO-2008157273-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-24 WO disclosed