Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.32 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754754 | 0.86 | CAMK2A (0.41) | MEP1BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4754828 | 0.84 | CYP3A4 (0.51) | MEP1BALDH1A1MAPTCYP3A4POLB | |
| SCHEMBL2340437 | 0.81 | CYP3A4 (0.37) | MEP1BALDH1A1MAPTCYP3A4POLB | |
| SCHEMBL3033047 | 0.81 | CYP3A4 (0.38) | MEP1BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13481896 | 0.81 | CYP3A4 (0.42) | MEP1BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13984460 | 0.80 | TDP1 (0.44) | MEP1BALDH1A1MAPTPOLBLMNA | |
| SCHEMBL3023318 | 0.80 | CYP3A4 (0.38) | MEP1BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13984632 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTCYP3A4POLBLMNA | |
| SCHEMBL4754790 | 0.78 | CYP3A4 (0.44) | ALDH1A1MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4754909 | 0.77 | THRA (0.36) | ALDH1A1MAPTCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157273-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157330-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157330-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157273-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |