Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 6/20 | 0.47 |
| ▸ | CNR2 | P34972 | 6/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614239 | 0.95 | KDM4E (0.51) | KDM4ECNR1CNR2HCAR3LMNA | |
| SCHEMBL5250642 | 0.88 | LMNA (0.47) | KDM4EHCAR3LMNAMAPTGRN | |
| SCHEMBL23115836 | 0.85 | KDM4E (0.51) | KDM4ELMNAMAPTGABRPGABRD | |
| SCHEMBL29834872 | 0.83 | SMN1; SMN2 (0.44) | KDM4ECNR1CNR2MAPTPOLB | |
| SCHEMBL30970919 | 0.81 | GAA (0.49) | KDM4ELMNAMAPTGABRPGABRD | |
| SCHEMBL710008 | 0.81 | MAPT (0.56) | KDM4ELMNAMAPTGRNSORT1 | |
| SCHEMBL27682187 | 0.81 | KDM4E (0.46) | KDM4ECNR1CNR2LMNAMAPT | |
| SCHEMBL21766174 | 0.80 | KDM4E (0.47) | KDM4ELMNAMAPTGABRPGABRD | |
| SCHEMBL28820586 | 0.80 | CNR1 (0.71) | KDM4ECNR1CNR2HCAR3GRN | |
| SCHEMBL19436521 | 0.80 | KDM4E (0.47) | KDM4ELMNAMAPTGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | claimed |