SCHEMBL4754960

SCHEMBL4754960

CC(CNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)C(O)C1O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.86
ADORA2A P29274 2/20 0.86
ADORA1 P30542 2/20 0.86
ADORA2B P29275 1/20 0.86
TP53 P04637 2/20 0.72
SLC29A1 Q99808 1/20 0.72
TDP1 Q9NUW8 1/20 0.72
NFKB1 P19838 2/20 0.69
TSHR P16473 2/20 0.69
THPO P40225 1/20 0.69
CYP3A4 P08684 1/20 0.69
ALOX12 P18054 1/20 0.69
HIF1A Q16665 1/20 0.69
ALDH1A1 P00352 1/20 0.69
HPGD P15428 1/20 0.69
PMP22 Q01453 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9793385 1.00 ADORA3 (0.86) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL9793357 1.00 ADORA3 (0.86) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL6852552 0.92 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL6852543 0.92 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL6659538 0.90 ADORA2A (0.73) ADORA3ADORA2AADORA1ADORA2BTSHR
SCHEMBL9793425 0.89 ADORA3 (0.83) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL10683936 0.88 ADORA2A (0.86) ADORA3ADORA2AADORA1ADORA2BTSHR
SCHEMBL10683942 0.88 ADORA2A (0.86) ADORA3ADORA2AADORA1ADORA2BTSHR
SCHEMBL20626289 0.87 ADORA3 (0.76) ADORA3ADORA2AADORA1ADORA2BTP53
SCHEMBL20626287 0.87 ADORA3 (0.76) ADORA3ADORA2AADORA1ADORA2BTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009002507-A1 COMPOSITIONS AND METHODS FOR TREATING MEDICAL CONDITIONS COMBINATORX, INCORPORATED (US) 2008-12-31 WO disclosed
EP-1993540-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS CombinatoRx, Incorporated (US) 2008-11-26 EP disclosed
EP-1956906-A2 METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MEDICAL CONDITIONS CombinatoRx, Incorporated (US) 2008-08-20 EP disclosed
WO-2007103373-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS COMBINATORX, INCORPORATED (US) 2007-09-13 WO disclosed
WO-2007056457-A2 METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MEDICAL CONDITIONS COMBINATORX, INCORPORATED (US) 2007-05-18 WO disclosed
EP-0689405-A4 METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE GENSIA INC (US) 1996-09-11 EP disclosed
EP-0689405-A1 METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE GENSIA, INC. (US) 1996-01-03 EP disclosed
WO-1994021195-A1 METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE GENSIA, INC. (US) 1994-09-29 WO disclosed