Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22143945 | 1.00 | ADRA2A (0.50) | ADRA2AMAP3K14TERTHTR1AP2RX7 | |
| SCHEMBL8291514 | 0.82 | MAP3K14 (0.57) | ADRA2AMAP3K14HTR1AADRA2BADRA1A | |
| SCHEMBL13506581 | 0.82 | MAP3K14 (0.47) | ADRA2AMAP3K14HTR1A | |
| SCHEMBL2593064 | 0.81 | CYP19A1 (0.41) | ADRA2AMAP3K14TERT | |
| SCHEMBL25166675 | 0.79 | MAP3K14 (0.45) | ADRA2AMAP3K14HTR1AP2RX7ADRA2B | |
| SCHEMBL6026797 | 0.79 | MAP3K14 (0.51) | ADRA2AMAP3K14P2RX7JAK2JAK3 | |
| SCHEMBL4795376 | 0.79 | ADRA2A (0.50) | ADRA2ATERTJAK2JAK3JAK1 | |
| SCHEMBL4753561 | 0.79 | ADRA2A (0.50) | ADRA2ATERTP2RX7JAK2JAK3 | |
| SCHEMBL25166562 | 0.79 | ADRA2A (0.50) | ADRA2AMAP3K14HTR1AADRA2BADRA1A | |
| SCHEMBL14197670 | 0.79 | ADRA2A (0.50) | ADRA2AMAP3K14TERTJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151927-A2 | 6-N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | NYCOMED GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |
| EP-1369490-B1 | Method of preparing a composition containing hygromycin A and epi-hygromycin | PFIZER PROD INC (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1369490-A1 | Method of preparing a composition containing hygromycin A and epi-hygromycin | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1075483-B1 | HYGROMYCIN A DERIVATIVES | PFIZER PROD INC (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6313100-B1 | ANTIBACTERIAL, ANTIPROTOZOA AGENTS | PFIZER INC | 2001-11-06 | — | — | US | disclosed |
| EP-1075483-A2 | HYGROMYCIN A DERIVATIVES | Pfizer Products Inc. (US) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057125-A2 | HYGROMYCIN A DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-11-11 | — | — | WO | disclosed |